(University of Western Cape, 2020) Lyimo, Germana Vincent; Ajayi, Fanelwa
Candida albicans is a clinical fungal isolate that is most frequently isolated from
different host niches, and is implicated in the pathogenesis of several fungal infections,
including oral candidiasis. The pathogenesis and antifungal resistance mechanisms of Candida
species are complex and involve several pathways and genes. Oral candidiasis incidence rates
are rapidly increasing, and the increase in resistance to conventional antifungals has led to the
need to develop innocuous and more efficacious treatment modalities. The purpose of this
study was to explore a single pot process for phytosynthesis of zinc oxide nanoparticles (GZnO
NPs) and to assess their antifungal potential.