Browsing by Author "van Niekerk, Johan"

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    Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa
    (Public Library of Science, 2020) Coetzee, Renier; Johnson, Yasmina; van Niekerk, Johan
    Inappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was prescribed potentially inappropriately in 6.5% of elderly patients. An analysis of prescriptions from the Chronic Dispensing Unit in the Western Cape revealed that amitriptyline was one of the most common medicines prescribed without a suitable diagnosis listed on the prescription.
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    The formulation and evaluation of indomethacin tablets
    (University of the Western Cape, 1998) van Niekerk, Johan
    The overall objective of this research is to attempt to produce, by direct compression, indomethacin tablets which have good dissolution characteristics and an improved bioavailability profile, when compared to the capsule formulations currently available. In order to use the direct compression method, the solubilized form of indomethacin should have good flow properties, as well as a small bulk volume for incorporation into reasonably sized tablets.