Browsing by Author "Uebel, R.A."
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Item Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide(Academic Journals, 2011) Ebrahim, Naushaad; Uebel, R.A.A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results indicated direct COX-2 enzyme inhibition by the H. procumbens extract due to possible synergistic activity of active components in the extract, which include harpagide and harpagoside.