Browsing by Author "Roomaney, Imaan Amina"

Now showing 1 - 8 of 8
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    CranDentSA registry: Advancing orodental and craniofacial anomalies research in South Africa
    (University of the Western Cape, 2024) Roomaney, Imaan Amina; Kabbashi, Salma; Chetty, Manogari
    “A dental anomalies registry is crucial for advancing the field by providing essential epidemiological data and guiding future research, diagnosis, and treatment of dental and other developmental disorders.” Dental anomalies are often associated with rare diseases and reflect pathological events intrinsic to tooth development or secondary systemic dysregulation. Dental anomalies can aid in the diagnosis of rare diseases and may share a common aetiopathogenesis to rare diseases. The lack of data available in South Africa hampers comprehensive understanding and effective management. The CranDentSA Registry aims to establish a patient-centric database to document and monitor orodental and craniofacial anomalies in South Africa. The registry will aid in understanding the epidemiology, enhance phenotype delineation, assess impact, evaluate the management of these anomalies, enhance patient care, facilitate interdisciplinary collaboration, and contribute to global research efforts.
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    Craniofacial, dental, and molecular features of Pyle disease in a South African child
    (Springer Nature, 2022) Chetty, Manogari; Roomaney, Imaan Amina; Oosterwyk, Chandré
    Pyle Disease (PD), or familial metaphyseal dysplasia [OMIM 265900], is a rare autosomal recessive condition leading to widened metaphyses of long bones and cortical bone thinning and genu valgum. We detail the oro-dental and molecular findings in a South African patient with PD. The patient underwent clinical, radiographic and molecular examinations. An exfoliated tooth was analysed using scanning electron microscopy and was compared to a control tooth. The patient presented with marked Erlenmeyer-flask deformity (EFD) of the long bones and several Wormian bones. His dental development was delayed by approximately three years. The permanent molars were mesotaurodontic. The bones, including the jaws and cervical vertebrae, showed osteoporotic changes.
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    The evolution of the nosology of osteogenesis imperfecta
    (Wiley-Blackwell, 2021) Chetty, Manogari; Roomaney, Imaan Amina; Beighton, Peter H.
    Osteogenesis imperfecta (OI) is a relatively common genetic skeletal disorder with an estimated frequency of 1 in 20 000 worldwide. The manifestations are diverse and although individually rare, the several different forms contribute to the production of a significant number of affected individuals with considerable morbidity and mortality. During the last decade, there have been extensive molecular investigations into the etiology of OI and these advances have direct relevance to the medical management of the disorder, and the purpose of this review is to document the history and evolution of the nosology of OI. The current nosology, based on molecular concepts, which are crucial in the identification of genotype‐phenotype correlations in persons with OI, is also outlined.
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    Managing vertical dimensions in patients with Amelogenesis Imperfecta: A case report
    (Wiley Open Access, 2022) Farao, Warren; Roomaney, Imaan Amina
    Amelogenesis imperfecta (AI) is a heterogeneous group of conditions character-ized by inherited developmental defects of enamel. Patients with AI often have progressive and severe loss of occlusal vertical dimensions (OVD), resulting in challenging dental rehabilitation. In this case report, we present the management of a 24- year- old male patient who previously underwent orthodontics, direct and indirect restorations, and continued to have progressive tooth wear. His vertical dimensions were restored in two phases, firstly with provisional restorations at the improved OVD, followed by a combination of monolithic zirconia and lith-ium disilicate full- coverage crowns. A removable acrylic appliance was then con-structed to protect his teeth.
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    Radiographic patterns of sella turcica shape in osteogenesis imperfecta: A pilot study in a South African cohort
    (University of the Western Cape, 2025) Roomaney, Imaan Amina; Walters, J; Chetty, Manogari
    Background: The sella turcica (ST), a readily identifiable structure on lateral cephalograms and cone beam computed tomography (CBCTs), is important in dental and craniofacial assessment. Osteogenesis imperfecta (OI) is associated with cranial base abnormalities, including distinct radiographic ST shapes. Patterns of ST morphology are relevant in understanding the pathophysiology of the neurocranium. The anterior part is derived from neural crest cells, and the posterior wall cartilage develops under the influence of the notochord. Results: Eighteen OI patients were included, fifteen of whom were diagnosed with OI type 3 (OI3), with eleven (73%) confirmed to have pathogenic variants in FKBP10. Figure 1 provides examples of STs identified in this study. Figure 2 provides statistical findings. Statistical analysis revealed no significant difference in ST shape distribution between OI1 and OI3 subtypes.
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    Sella turcica morphology in patients with genetic syndromes: Protocol for a systematic review
    (JMIR Publications Inc., 2020) Roomaney, Imaan Amina; Chetty, Manogari
    Background: The sella turcica is an important anatomical reference used in orthodontics and the evaluation of craniofacial growth. Studies have found an association between variations in sella turcica morphology in patients with certain syndromes affecting the craniofacial complex. It is hypothesized that each related syndrome or pathological condition is associated with a specific pattern of malformation of the sella turcica. Objective: This study outlines the protocol for a systematic review that aims to determine if genetic syndromes involving the craniofacial complex are associated with abnormal radiographic sella turcica morphology and if there is a pattern of malformation that is consistent with each syndrome. Methods: An electronic database search was conducted using a planned search strategy to identify relevant studies. We included primary studies evaluating the morphology of the sella turcica based on imaging from a lateral view. Specifically, only studies with postnatal human participants with genetic syndromes involving the craniofacial complex were included in this review. We placed no restrictions on the language or time frame of these studies. Based on the search findings, studies were further screened for relevance and eligibility by two independent reviewers. Data were extracted from the selected studies. We assessed the selected studies for risk of bias and quality by using risk of bias tools from the Joanna Briggs Institute.
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    Taurodontism in dental genetics
    (Springer Nature, 2021) Chetty, Manogari; Roomaney, Imaan Amina; Beighton, Peter
    Taurodontism is a dental anomaly defined by enlargement of the pulp chamber of multirooted teeth with apical displacement of the pulp floor and bifurcation of the roots. Taurodontism can be an isolated trait or part of a syndrome. A study was conducted to document the dental and craniofacial aspects of genetic thin bone disorders in South Africa. Sixty-four individuals with Osteogenesis imperfecta (OI), one individual with Pyle disease and one with Torg-Winchester syndrome respectively, were assessed clinically, radiographically and at a molecular level. Ten patients with OI XI and those with Pyle disease and Torg-Winchester syndrome had taurodontism. Taurodontism has been identified in several genetic disorders necessitating cognizance of the possible existence and implications of this characteristic when managing patients in the dental environment. Further studies should be directed toward identifying the incidence, etiology, and molecular pathways leading to taurodontism and its relationship to genetic syndromes.
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    Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta-analysis
    (Wiley Open Access, 2021) Roomaney, Imaan Amina; Holmes, Haly Karen; Engel, Mark M.
    This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications.Five randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random-effects meta-analysis. Methodological quality assessment and heterogeneity were performed using peer-reviewed criteria. PROSPERO registration: CRD42017076.