Browsing by Author "Mulder van Staden, Sune"

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    COVID-19: Focus on masks and respirators – Implications for oral health-care workers
    (2020) Mulder, Riaan; Layloo, Nazreen; Mulder van Staden, Sune
    The emergence of the novel human coronavirus (Severe acute respiratory syndrome coronavirus 2; abbreviated as: SARS-CoV-2) generally known as COVID-19 is a global health concern.1 On 11 February 2020, the World Health Organization (WHO) named the novel viral pneumonia as “Corona Virus Disease” (COVID-19). The International Committee on Taxonomy of Viruses (ICTV) suggested this novel coronavirus be named “SARS-CoV-2” due to the phylogenetic and taxonomic analysis of this virus.2 Thus, both terms are utilised interchangeably in the literature. Undoubtedly, COVID-19 will change the way we practice dentistry with vast implications for Oral health-care workers (OHCW) and practice staff. Additionally, if rigorous safety protocols are not implemented based on a risk assessment outlined by the CDC, the dental practice can potentially become a nexus for disease transmission due to the high volume of aerosol production on a daily basis. Personal protective equipment (PPE), staff training and practice disinfection protocols have now especially become important in the light of the current pandemic. This is not a fight that one profession can fight alone, it requires joint efforts, it requires all stakeholders, it requires foresight and it requires us to put the health of the communities above all else.
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    IL-1 genotype association with a diagnosis of periodontitis: in vivo study.
    (J Dent Res, 2023-09-07) Mulder van Staden, Sune; Mulder, Riaan
    Bcakground: Aim: This study aimed to evaluate the periodontal risk status based on the result of the Genotype Interleukin- 1®test in patients diagnosed with chronic periodontitis. Objective: To evaluate a correlation between Genotype Interleukin- 1® positivity and bacterial species at baseline for low and high-risk patients. To evaluate a correlation between Genotype Interleukin- 1® positivity and clinical parameters (PPD, REC,CAL, BOP, PI) of periodontal disease of low and high-risk patients at baseline. Methods: The periodontal risk status of 25 patients diagnosed with chronic periodontitis was assessed performing a buccal cheek swap with the Genotype Interleukin- 1® kit at baseline (prior to starting periodontal treatment). A positive Genotype Interleukin- 1® (indicating high risk) was then evaluated against bacterial species parameters and the presence of clinical parameters indicative of periodontitis in patients indicated a slow or high risk. Results: 7 of the 25 patients were identified as high risk for the development of periodontitis (Genotype Interleukin- 1 positive). There were no significant differences in the mean values comparing the baseline bacterial species parameter sand clinical parameters between high and low-risk groups. Conclusions: The conclusion was that irrespective of patients having a high versus low risk genotype at baseline, the differences in the bacterial and clinical parameters were not statistically significant.
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    In-vitro study to investigate the antimicrobial and cytotoxic activity of a periodontal pocket gel: Pocket-X® gel By
    (University of the Western Cape, 2024) Moloi, Mpho; Mulder van Staden, Sune
    Background. Periodontitis is a common oral disease resulting in periodontal breakdown and ultimately tooth loss. It is characterized by chronic inflammation of the periodontal tissues brought on by the formation and accumulation of substantial quantities of dental biofilm in a susceptible host. Numerous interventions are available for improving the management of periodontitis, including products such as the in situ gel Pocket-X® gel. There are limited studies assessing the efficacy of Pocket-X® gel, particularly in vitro to draw from. This study was aimed to evaluate the in vitro antimicrobial and potential cytotoxicity of Pocket-X® gel. Materials and methods. The antimicrobial efficacy of Pocket-X® gel was tested utilizing Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis (P.g.) and Candida albicans (C.a.), which are pathogens commonly associated with the initiation and development of periodontitis. The zones of inhibition were used to measure the efficacy of Pocket-X® gel by well-diffusion method on Meuller-Hinton Agar over time. The potential cytotoxicity effect of Pocket-X® gel was assessed on buccal fibroblasts to simulate the oral tissue through the calculation of the percentage survival of buccal fibroblasts on tissue culture plates. Results. Pocket-X® gel demonstrated sustained antimicrobial effects over the 28 days test period across the three test organisms with zone of inhibition (ZOI) of 11.70(±0.78), 10.75(±0.68), and 11.86(±1.11) mm in diameter, respectively.
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    Peri-implant health and disease: A cross-sectional study
    (University of the Western Cape, 2023) Mahlangu, Sibongile Priscilla; Mulder van Staden, Sune
    Introduction: Preventive strategies that address peri-implant diseases can only be developed appropriately when there is thorough knowledge of the prevalence of disease based on standardized assessment protocols and case definitions Aims and objectives: The aim of this cross-sectional study was to evaluate the prevalence of the peri-implant health and disease in patients who received implants during the period 2012-2018 in the Department Oral Medicine and Periodontics Clinic, University of the Western Cape. Methods: The information for the vectors of the Implant Disease Risk Assessment tool was obtained from the files of participants. A comprehensive periodontal examination was performed.