Browsing by Author "Mouton, J.P"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Adult medical emergency unit presentations due to adverse drug reactions in a setting of high HIV prevalence
    (African Federation for Emergency Medicine, 2021) Igumbor, E; Mouton, J.P; Jobanputra, N
    South Africa has the world's largest antiretroviral treatment programme, which may contribute to the adverse drug reaction (ADR) burden. We aimed to determine the proportion of adult non-trauma emergency unit (EU) presentations attributable to ADRs and to characterise ADR-related EU presentations, stratified according to HIV status, to determine the contribution of drugs used in management of HIV and its complications to ADR-related EU presentations, and identify factors associated with ADR-related EU presentation. Methods: We conducted a retrospective folder review on a random 1.7% sample of presentations over a 12-month period in 2014/2015 to the EUs of two hospitals in Cape Town, South Africa. We identified potential ADRs with the help of a trigger tool. A multidisciplinary panel assessed potential ADRs for causality, severity, and preventability.