Browsing by Author "Gunes, Sezgin"

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    Microtubular dysfunction and male infertility
    (Korean Society for Sexual Medicine and Andrology, 2018) Gunes, Sezgin; Sengupta, Pallav; Henkel, Ralf; Alguraigari, Aabed; Sinigaglia, Mariana Marques; Kayal, Malik; Joumah, Ahmad; Agarwal, Ashok
    Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.
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    Smoking‐induced genetic and epigenetic alterations in infertile men
    (Wiley, 2018) Gunes, Sezgin; Mahmutoglu, Asli Metin; Arslan, Mehmet Alper; Henkel, Ralf
    Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful effects of cigarette smoking on seminal parameters. Some studies could not establish a negative effect by tobacco smoking on sperm quality and function, whereas others have found a significant reduction in sperm quality and function. This study reviews the components in cigarette smoke and discusses the effects of smoking on male fertility by focusing extensively on smoking‐induced genetic and epigenetic alterations in infertile men. Chromosomal aneuploidies, sperm DNA fragmentation and gene mutations are discussed in the first section, while changes in DNA methylation, chromatin remodelling and noncoding RNAs are discussed in the second section as part of epigenetic alterations.