Browsing by Author "Elbardisi, Haitham"

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    Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia
    (John Wiley and Sons Inc, 2021) Elbardisi, Haitham; Majzoub, Ahmad; Daniel, Christiana; Al, Fadwa Al; Henkel, Ralf
    In this study, we investigated the prevalence of sexual dysfunction among males with advanced chronic kidney disease and the effect of treating hyperprolactinemia among these patients. In this prospective study, patients were assessed with history, physical examination, hormonal assessment, and two questionnaires, IIEF and AIPE. Patients with hyperprolactinemia received treatment with cabergoline 0.5 mg once per week for 6 months and were re-evaluated. A total of 102 patients were included in this study, 75 (73.53%) were on hemodialysis, 13 (12.75%) on peritoneal dialysis and 14 (13.73%) on medical treatment alone. Ninety (88.24%) patients had premature ejaculation, 85 (83.33%) had anything from mild-to-moderate-to-severe erectile dysfunction. The incidence of hypogonadism and hyperprolactinemia was 34.4%. Patients treated with cabergoline (n = 26) showed a significant increase in LH levels (p = .003) and a significant decrease in prolactin levels (p = .003). Testosterone levels and the incidence of erectile dysfunction or premature ejaculation did not improve significantly. There is a high incidence of sexual dysfunction among patients. Treatment of hyperprolactinemia is effective in correcting prolactin levels, but does not improve erectile dysfunction or premature ejaculation. Therefore, treating hyperprolactinemia is not an overall effective treatment for erectile dysfunction in these patients.
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    Impact of body composition analysis on male sexual function : A metabolic age study
    (Frontiers in Endocrinology, 2023-01) Leisegang, Kristian; Henkel, Ralf; Majzoub, Ahmad; Elbardisi, Haitham; Madani, Sarah; Mahdi, Mohamed; Agarwal, Ashok; Khalafalla, Kareim; Alsaid, Sami; Arafa, Mohamed
    Metabolic Age (MetAge) and body composition analysis may reflect an individual’s metabolic status, which is believed to influence male sexual and gonadal functions. Although erectile dysfunction (ED) and hypogonadism are increasingly prevalent with age, they are also detected among younger men. This study aims to assess the impact of MetAge and body composition on male sexual and gonadal status overall, and particularly in men younger than 40 years of age.
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    Impact of body composition analysis on male sexual function: A metabolic age study
    (Frontiers Media, 2023) Majzoub, Ahmad; Elbardisi, Haitham; Henkel, Ralf
    Metabolic Age (MetAge) and body composition analysis may reflect an individual’s metabolic status, which is believed to influence male sexual and gonadal functions. Although erectile dysfunction (ED) and hypogonadism are increasingly prevalent with age, they are also detected among younger men. This study aims to assess the impact of MetAge and body composition on male sexual and gonadal status overall, and particularly in men younger than 40 years of age.
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    Racial differences in male fertility parameters in 2,996 men examined for infertility in a single center
    (Taylor and Francis Ltd., 2025) Henkel, Ralf; Elbardisi, Haitham; Majzoub, Ahmad
    Objectives: Several studies have demonstrated racial variations in various diagnostic clinical parameters in different fields of medicine including andrology. Yet, clinical andrological diagnostic is following the lower reference values recommended by the World Health Organization irrespective of the racial descent of men. Therefore, this study aimed to investigate racial differences in hormonal and semen parameters including sperm DNA fragmentation (SDF) and seminal oxidative stress in a large group of patients from Sub-Saharan, Caucasian, Central/South Asian, Middle Eastern, North African, and Southeast Asian descent. Methods: In a total of 2,996 infertile men, testis volume, sperm concentration, total sperm count, total and progressive motility, normal morphology, sperm vitality, SDF, oxidation-reduction potential (ORP), and standard hormones were determined and compared. Results: Significant racial differences for various parameters including the incidence of normal ranges values in the racial groups were found. The highest mean sperm concentration had men of Central/South Asian descent (median: 38.0 × 106/mL) while Southeast Asian men had the lowest (median: 22.0 × 106/mL; p < 0.0001). The highest total sperm motility (median: 55.0%) was observed in Caucasian, Central/South Asian, and Southeast Asian men, while Sub-Saharan African men had the lowest (median: 45.0%; p < 0.0001). For SDF, Caucasian men had the lowest sperm DNA fragmentation (median: 16.0%) and ORP values (median: 1.3 mV/106 sperm/mL) as compared to Central/South Asian men (median: 28.0%; p = 0.0263) and Southeast Asian men (median: 2.4 mV/106 sperm/mL; p = 0.0045), respectively. Conclusions: Our results show not only significant racial differences for many of the parameters investigated but also for the incidence of normal values. Therefore, it might be prudent to revisit the concept of globally standardized reference values for all men. Yet, as a limitation, the small number (53) of Caucasian men needs to be mentioned. Larger studies that include functional sperm parameters need to be conducted.