Browsing by Author "Baker, Thomas K."

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    Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants
    (Elsevier, 2016) Goldstein, Keith M.; Seyler, David E.; Baker, Thomas K.
    Due to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous tubule culture model [1], [2], [3] that supports spermatogenesis through meiosis II, including the formation of round spermatids. We used this system to evaluate the toxicity of four known testicular toxicants: 1,3-dinitrobenzene (DNB), 2-methoxyacetic acid (MAA), bisphenol A (BPA), and lindane over 21 days of culture.