Research Articles (Biotechnology)

Permanent URI for this collection

https://hdl.handle.net/10566/502

Browse

Browsing by Author "Adewale, Olusola Bolaji"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles
    (Elsevier, 2020) Roux, Saartjie; Adewale, Olusola Bolaji; Potts-Johnson, Sotonye S.
    The development of cancer therapies has become difficult due to high metastasis, and lack of tissue selectivity, which in most cases affects normal cells. Demand for anticancer therapy is therefore increasing on daily basis. Gold nanoparticles (AuNPs) have many applications in biomedical field. Biological synthesis of AuNPs using aqueous extract of Crassocephalum rubens (AECR) was designed to investigate the in vitro anticancer potential. The synthesized AuNPs were characterized by UV–vis spectroscopy, high-resolution transmission electron microscopy, and Fourier transform infrared spectroscopy. The characterization results showed the formation of green AuNPs of wavelength 538 nm, and mostly spherical AuNPs with 20 5 nm size. Significant anticancer activity of the AECRAuNPs on MCF-7 and Caco-2 cells was noted at higher concentrations (125 and 250mg/mL) during 24 and at all concentrations tested during 48 h. It can therefore be concluded that AECR leaves can mediate stable AuNPs with anticancer properties.
  • Thumbnail Image
    Item
    Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
    (SAGE, 2020) Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Adewale, Olusola Bolaji
    The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 by the World Health Organization. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). There is limited information on COVID-19, and treatment has so far focused on supportive care and use of repurposed drugs. COVID-19 can be transmitted via person-to-person contact through droplet spread. Some of the recommended precautionary measures to reduce the rate of disease spread include social distancing, good hygiene practices, and avoidance of crowded areas. These measures are effective because the droplets are heavy and can only travel approximately 1 meter in the air, settling quickly on fixed surfaces. Promising strategies to combat SARS-CoV-2 include discovery of therapeutic targets/drugs and vaccines. In this review, we summarize the epidemiology, pathophysiology, and diagnosis of COVID-19. We also address the mechanisms of action of approved repurposed drugs for therapeutic management of the disease.