Research Articles (Biotechnology)

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Browsing by Author "Adeniyi, Oladele Vincent"

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    Prevalence, patterns and determinants of dyslipidaemia among South African adults with comorbidities
    (Nature Research, 2022) Masilela, Charity; Adeniyi, Oladele Vincent; Benjeddou, Mongi
    The present study assessed the prevalence, patterns and determinants of dyslipidaemia among South African adults with multi-morbidities. In this study, 614 individuals with DM and hypertension were recruited. Dyslipidaemia was defined as elevated levels of total cholesterol (TC) ≥ 5.2 mmol/L and/or low-density lipoprotein cholesterol (LDL-C) ≥ 2.6 mmol/L, triglycerides (TG) ≥ 1.8 mmol/L and low high-density lipoprotein cholesterol (HDL-C) < 1 mmol/L for men and < 1.2 mmol/L for women. Multivariate regression model (adjusted) analysis was used to identify the significant determinants of dyslipidaemia. The prevalence of dyslipidaemia was 76.7% (n = 471), with females showing the highest prevalence 357 (75.79%).
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    Single nucleotide polymorphisms in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension
    (MDPI, 2022) Masilela, Charity; Adeniyi, Oladele Vincent; Benjeddou, Mongi
    This study describes the single nucleotide polymorphisms (SNPs) in amlodipineassociated genes and assesses their correlation with blood pressure control among South African adults with hypertension. Methods: In total, 304 hypertensive patients on amlodipine treatment belonging to the indigenous Swati, Xhosa and Zulu population groups of South Africa were recruited between June 2017 and June 2019. Participants were categorized into: controlled (blood pressure < 140/90 mmHg) and uncontrolled (blood pressure 140/90 mmHg) hypertension. Thirteen SNPs in amlodipine pharmacogenes with a high PharmGKB evidence base were selected and genotyped using MassArray (Agena BioscienceTM).