Philosophiae Doctor - PhD (Maxillo-Facial & Oral Surgery)

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Browsing by Author "Manogari Chetty"

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    Clinicopathological profile of ameloblastomas among Sudanese patients
    (University of the Western Cape, 2024) Mashail Mahmoud Hamid; Manogari Chetty
    Background: Ameloblastoma is considered the most common benign epithelial odontogenic tumor with a high rate of recurrence if not removed adequately. Knowledge of early events leading to and promoting tumorigenesis in ameloblastoma remains limited, partly because studies directed at identifying molecular factors and events that initiate, and drive tumorigenesis are inconclusive. Exploring the genetic aspects and correlating that to the biological behavior of ameloblastoma and its subtypes in a big sample size may help predict the clinical behavior and prognosis to embark on the most suitable treatment protocol. Moreover, it can objectively assess post-therapeutic response, particularly in recurrent cases of ameloblastoma. Many epidemiological studies on ameloblastoma have been conducted worldwide, however, despite the high frequency and aggressive behavior of this tumor in Sudan, there are no recent published reports regarding the prevalence of ameloblastoma, even though many patients are diagnosed and treated at Khartoum Teaching Dental Hospital (the main OMS referral hospital in Sudan). Most of these patients present with large-sized aggressive tumors with massive bone destruction and soft tissue invasion; cases with recurrence and malignant transformation are often seen there as well. Moreover, several markers and genes involved in the pathogenesis of ameloblastoma have been investigated worldwide; however, no similar studies have been conducted in Sudan, therefore, further investigation and studies in this field are needed.