Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
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Date
2017
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients that are infected with HIV
and those without HIV infection. Therefore, the objective of this current study was
firstly, to find out ethionamide plasma concentration using the LC-MS method;
secondly, to evaluate and compare the pharmacokinetics of ethionamide in MDR-TB
patients infected with and without HIV infection; thirdly, to examine the effects of
ARVs and kidney impairment on the PK of ethionamide and fourthly, to find out the
consequence of sex and age on ETH PK parameters.
Description
Magister Pharmaceuticae - Mpharm
Keywords
Multidrug-resistant tuberculosis, Human immunodeficiency virus, Mycobacterium tuberculosis, Antiretroviral agents, Ethionamide, Pharmacokinetics, Plasma concentrations, Liquid chromatography, Mass spectrometry