Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa

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dc.contributor.advisorWard, Kim
dc.contributor.advisorDube, Admire
dc.contributor.authorSuleiman, Reem Abdallah S.
dc.date.accessioned2018-08-02T12:27:41Z
dc.date.accessioned2024-10-29T13:17:58Z
dc.date.available2018-08-02T12:27:41Z
dc.date.available2024-10-29T13:17:58Z
dc.date.issued2017
dc.descriptionMagister Scientiae - MSc (Pharmaceutical Chemistry)en_US
dc.description.abstractThe rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for quality assessment of these medicines. South Africa has the worst human immunodeficiency virus (HIV) epidemic profile in the world; consequently, it has rolled out the world's largest antiretroviral ARV programme. With increasing market penetration of generic medicine in South Africa and especially ARVs, there is a call for stringent quality control mechanisms following the marketing approval (post-market quality control) of these medications. Unfortunately, evidence suggests that the World Health Organisation (WHO) recommendations for this aspect of quality assurance is not met by most Medicine Regulatory Authorities. In South Africa and many other countries this is attributed to a lack of physical and financial resources to enforce effective post-marketing surveillance (PMS) of all pharmaceuticals available in the country.en_US
dc.identifier.urihttps://hdl.handle.net/10566/16342
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectAntiretroviralsen_US
dc.subjectDissolutionen_US
dc.subjectEfavirenzen_US
dc.subjectEmtricitabineen_US
dc.subjectFixed-dose combinationen_US
dc.subjectHPLCen_US
dc.subjectPost-market qualityen_US
dc.subjectQuality testsen_US
dc.subjectTenofovir disoproxil fumarateen_US
dc.subjectValidationen_US
dc.titlePost-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africaen_US
dc.typeThesisen_US

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