Dexamethasone's impact on LPS-induced inflammation of blood-brain barrier endothelial cells
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Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
The blood-brain barrier (BBB) serves as a protective and regulatory barrier between the blood and the brain. Microvascular endothelial cells provide homeostatic regulation of the central nervous system (CNS). BBB integrity is compromised by inflammation, which contributes to a wide range of neurological disorders. It has been shown that glucocorticoids (GCs) have anti-inflammatory functions on a variety of cells. A particular example is Dexamethasone (Dex), which is used for the treatment of inflammatory conditions and has recently been found to be effective in attenuating COVID-19. Aim: The purpose of this study was to determine whether low or high concentrations of Dex can attenuate the inflammatory response induced by LPS on the in vitro BBB model.
Description
>Magister Scientiae - MSc
Keywords
Blood-brain barrier (BBB), Central nervous system (CNS), Lipopolysaccharide (LPS), COVID-19, Induced inflammation