Reactive oxygen species and male reproductive hormones

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dc.contributor.authorDarbandi, Mahsa
dc.contributor.authorDarbandi, Sara
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorSengupta, Pallav
dc.contributor.authorDurairajanayagam, Damayanthi
dc.contributor.authorHenkel, Ralf
dc.contributor.authorSadeghi, Mohammad Reza
dc.date.accessioned2018-09-17T06:55:47Z
dc.date.available2018-09-17T06:55:47Z
dc.date.issued2018
dc.description.abstractReports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are numerous exogenous and endogenous factors that are able to induce excessive production of reactive oxygen species (ROS) beyond that of cellular antioxidant capacity, thus causing oxidative stress. In turn, oxidative stress negatively affects male reproductive functions and may induce infertility either directly or indirectly by affecting the hypothalamus-pituitary-gonadal (HPG) axis and/or disrupting its crosstalk with other hormonal axes. This review discusses the important exogenous and endogenous factors leading to the generation of ROS in different parts of the male reproductive tract. It also highlights the negative impact of oxidative stress on the regulation and cross-talk between the reproductive hormones. It further describes the mechanism of ROS-induced derangement of male reproductive hormonal profiles that could ultimately lead to male infertility. An understanding of the disruptive effects of ROS on male reproductive hormones would encourage further investigations directed towards the prevention of ROS-mediated hormonal imbalances, which in turn could help in the management of male infertility.en_US
dc.identifier.citationDarbandi, M. et al. (2018). Reactive oxygen species and male reproductive hormones. Reproductive Biology and Endocrinology, 16: 87en_US
dc.identifier.issn1477-7827
dc.identifier.urihttps://doi.org/10.1186/s12958-018-0406-2
dc.identifier.urihttp://hdl.handle.net/10566/4042
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherBMCen_US
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.status.ispeerreviewedTRUE
dc.subjectAntioxidantsen_US
dc.subjectHypothalamic-pituitary-gonadal axisen_US
dc.subjectMale infertilityen_US
dc.subjectOxidative stressen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectTestosteroneen_US
dc.titleReactive oxygen species and male reproductive hormonesen_US
dc.typeArticleen_US

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