Dental Aberrations in Osteogenesis imperfecta: A Systematic Review
| dc.contributor.author | Shnaiba, Amani Mukhtar M | |
| dc.date.accessioned | 2025-11-20T08:31:19Z | |
| dc.date.available | 2025-11-20T08:31:19Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Background: Osteogenesis imperfecta (OI), also known as “fragile bone disease”, is a heterogeneous group of genetic conditions affecting connective tissue, in particular bones and joints (Gover, et al., 2022; Prado, et al., 2023). Despite significant involvement of craniofacial tissues and teeth in several types of OI; these abnormalities are often eclipsed by severe syndromic features, resulting in the dental and craniofacial features being overlooked (Nguyen, et al., 2021). In our systematic review, we aim to determine the types of dental aberrations observed among patients with OI. Method: A search of electronic databases of Scopus, PubMed, Science Direct, Cochrane, and EBSCOhost was performed. The search time-frame was limited from 2000 to 2023. Only primary studies describing dental aberrations in post-natal humans with a confirmed diagnosis of OI were included. Two authors independently conducted data extraction according to a custom-designed data extraction sheet. A narrative review of the findings is provided. This review has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered with PROSPERO (CRD42020205063). Results: Our search of electronic databases identified 1011 articles. Of these, 38 articles were included in the review. The number of participants in these studies, which were performed in 17 different countries, ranged from 1 to 568. Common dental aberrations reported in patients with OI were malocclusion, in which Angle Class III malocclusion is the most common, and dentinogenesis imperfecta. Other aberrations included tooth discolouration, abnormal tooth shape, attrition, tooth agenesis, and disturbances in eruption. Fourteen of these studies had a low risk and 22 studies had a moderate to high risk of bias. This review provides a summary of the spectrum of OI-associated dental aberrations. The authors demonstrate the importance of dental practitioners being aware of these dental aberrations so that patients presenting with these features may receive the appropriate referrals. A multidisciplinary team approach is best suited to managing patients with OI to address their complex dental needs. The results of this review also underscore the need for further research expanding the knowledge base available on dental aberrations in patients with OI, particularly in terms of genotype-phenotype correlation, long-term prospective studies on disease natural history, treatment outcomes, and patient management protocols development. | |
| dc.identifier.uri | https://hdl.handle.net/10566/21434 | |
| dc.language.iso | en | |
| dc.publisher | University of the Western Cape | |
| dc.subject | Aberration and Bone fragility disease | |
| dc.subject | Dentinogenesis imperfecta | |
| dc.subject | Dental Malocclusion | |
| dc.subject | Ectopic eruption | |
| dc.subject | Dental implication of osteogensis imperfecta | |
| dc.title | Dental Aberrations in Osteogenesis imperfecta: A Systematic Review | |
| dc.type | Thesis |