In vivo effects of eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat

Simple item page
dc.contributor.authorSolomon, Michael
dc.contributor.authorErasmus, N.
dc.contributor.authorHenkel, Ralf
dc.date.accessioned2016-06-01T10:22:05Z
dc.date.available2016-06-01T10:22:05Z
dc.date.issued2013
dc.description.abstractAn aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. Forty-two male rats were divided into a control, low-dose (200 mg kg(-1) BW) and high-dose (800 mg kg(-1) BW) group (n = 14). Rats were force-fed for 14 days and then sacrificed. Total body and organ weights of the prostate, testes, epididymides, gastrocnemius muscle and the omentum were recorded. Moreover, testosterone concentration, sperm concentration, motility, velocity, vitality, acrosome reaction and mitochondrial membrane potential (MMP) were assessed. Whilst TA decreased BW by 5.7% (P = 0.0276) and omentum fat by 31.9% (P = 0.0496), no changes in organ weights were found for the prostate, testes and epididymides. Testosterone concentration increased by 30.2% (P = 0.0544). Muscle weight also increased, yet not significantly. Whilst sperm concentration, total and progressive motility and vitality increased significantly, MMP improved markedly (P = 0.0765) by 25.1%. Because no detrimental effect could be observed, TA appears safe for possible treatment of male infertility and ageing male problems.en_US
dc.description.accreditationISIen_US
dc.identifier.citationSolomon, M.C. et al. (2013). In vivo effects of eurycoma longifolia jack (tongkat ali) extract on reproductive functions in the rat. Andrologia, 46 (4): 339-48en_US
dc.identifier.issn0303-4569
dc.identifier.urihttp://hdl.handle.net/10566/2242
dc.identifier.urihttp://dx.doi.org/10.1111/and.12082
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherBlackwellen_US
dc.rights.urihttp://www.sherpa.ac.uk/romeo/issn/0303-4569/
dc.source.urihttp://dx.doi.org/10.1111/and.12082
dc.status.ispeerreviewedTRUE
dc.subjectBody weighten_US
dc.subjectTongkat Alien_US
dc.subjectComplementary medicineen_US
dc.subjectSperm parametersen_US
dc.subjectTestosteroneen_US
dc.titleIn vivo effects of eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the raten_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Solomon_In vivo effects_2013.pdf
Size:
1.23 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.55 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Medical Bioscience)