Molecular evolution of key receptor genes in primates and non-human primates
Loading...
Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Science Publishing Group
Abstract
African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in host resistance or susceptibility to tuberculosis. The validation of these genes in Mycobacterium tuberculosis infection makes them an excellent model system to investigate the mode of selective pressures that may act on pathogen defense genes. To
trace the evolutionary history of these genes, the report describes preliminary results for eight receptors human genes having either a significant or a possible association with Tuberculosis (TB). By using a combination of maximum likelihood
approaches, evidence of positive selection were detected for four genes. The analysis between species, nevertheless, shows a clear pattern of nucleotide variation mostly compatible with purifying selection.
Description
Keywords
Receptor genes, Tuberculosis, Phylogeny, Non-human primates, Adaptive evolution
Citation
Barbara Picone, Alan Christoffels. (2014). Molecular evolution of key receptor genes in primates and non-human primates. International Journal of Genetics and Genomics. 2(4): 57-61. doi: 10.11648/j.ijgg.20140204.12