HIV/Candida co-infection in Sub-Saharan African women on ART

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dc.contributor.authorAbrantes, Pedro Miguel dos Santos
dc.contributor.authorAfrica, Charlene W.J.
dc.date.accessioned2014-04-13T20:44:26Z
dc.date.available2014-04-13T20:44:26Z
dc.date.issued2013
dc.description5th FIDSSA Congress 2013: Champagne Sports Resort Drakensberg, KwaZulu Natal, South Africa - Poster Presentations.
dc.description.abstractINTRODUCTION: Sub-Saharan Africa has 23.5 million cases of HIV and is home to 92% of the world’s HIV-positive pregnant women of whom 24% die of pregnancy related complications. Oral candidiasis is a common condition in HIV-AIDS patients, caused by commensal yeasts which may colonise the mucous membranes of the mouth causing morbidity due to several factors including immunosuppression, smoking, poor nutrition and the use of antibiotics. Methods: One hundred and ninety-four South African and Cameroonian HIV-positive women participated in the study. Only subjects who had white pseudomembranous plaque on the tongue or visible oral candidiasis were included. Samples were collected by scraping the patient’s oral mucosa and tongue with a sterile swab. Candida species were differentiated using selective and chromogenic media and their susceptibility to antifungal drugs was tested using the TREK Sensititre system. Results and conclusion: One hundred and ninety-six isolates, representative of six Candida species were identified. C. albicans was the predominating species, with C. glabrata and C. dubliniensis being the more frequent of the non-albicans isolates. Azole drug resistance patterns were very high for C. albicans, while C. glabrata showed high resistance patterns to echinocandins drugs. The duration of ART could be associated with the presence of different Candida species but no concrete conclusions could be drawn concerning HIV/Candida co-infection when controlling for other risk factors such as HIV stage, pregnancy, age and treatment for tuberculosis. This may be a cause for concern, particularly in the case of pregnancy, where co-infection may pose a risk for maternal morbidity and mortality.en_US
dc.description.accreditationDepartment of HE and Training approved listen_US
dc.description.sponsorshipNational Research Foundation of South Africaen_US
dc.identifier.citationAfrica, C.W.J. & Abrantes, P.M.D.S. (2013). HIV/Candida co-infection in Sub-Saharan African women on ART. South African Journal of Epidemiology and Infection, 28(3): 245en_US
dc.identifier.issn1015-8782
dc.identifier.issn2220-1084
dc.identifier.urihttp://hdl.handle.net/10566/1073
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherInfectious Diseases Society of Southern Africa, the Sexually Transmitted Diseases Society of Southern and the Public Health Association of South Africa.en_US
dc.rights© 2013 Africa, Abrantes. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.status.ispeerreviewedtrue
dc.subjectCandidaen_US
dc.subjectWomenen_US
dc.subjectHIVen_US
dc.titleHIV/Candida co-infection in Sub-Saharan African women on ARTen_US
dc.typePosteren_US

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