Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes axis, contributing to the regulation of male reproductive potential and overall wellbeing. These hormones are also present in semen influencing sperm functions. Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated.
Description
Keywords
Obesity, Reproduction, Reproductive dysfunction, Infertility
Citation
Leisegang, K. et al. (2014). Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort. Reproductive Biology and Endocrinology, 12(1):34