Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms

dc.contributor.advisorCloete, Ruben Earl Ashley
dc.contributor.authorIsaacs, Darren Mathew
dc.date.accessioned2021-08-19T10:50:23Z
dc.date.accessioned2024-05-17T07:20:09Z
dc.date.available2021-08-19T10:50:23Z
dc.date.available2024-05-17T07:20:09Z
dc.date.issued2021
dc.description>Magister Scientiae - MScen_US
dc.description.abstractThe viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a high mutation rate as evidenced by the presence of a large number of subtypes and even strains that have become resistant to antiretroviral drugs. It remains inconclusive what effect this diversity in the form of naturally occurring polymorphisms/variants exert on IN in terms of its function, structure and susceptibility to IN inhibitory antiretroviral drugs. South Africa is home to the largest HIV-1 infected population, with (group M) subtype C being the most prevalent subtype. An investigation into IN is therefore pertinent, even more so with the introduction of the IN strand-transfer inhibitor (INSTI) Dolutegravir (DTG).en_US
dc.identifier.urihttps://hdl.handle.net/10566/15235
dc.language.isoenen_US
dc.publisherUniversity of Western Capeen_US
dc.rights.holderUniversity of Western Capeen_US
dc.subjectHIV-1en_US
dc.subjectSouth Africaen_US
dc.subjectIntegrase subtype Cen_US
dc.subjectProteinen_US
dc.subjectAntiretroviral drugsen_US
dc.titleMolecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphismsen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
isaacs_m_nsc_2021.pdf
Size:
4.19 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description: