Investigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugs

dc.contributor.advisorAucamp, Marique
dc.contributor.authorOkafor, Nnamdi Ikemefuna
dc.date.accessioned2023-05-17T09:39:15Z
dc.date.accessioned2024-05-15T07:16:51Z
dc.date.available2023-05-17T09:39:15Z
dc.date.available2024-05-15T07:16:51Z
dc.date.issued2022
dc.descriptionDoctor Pharmaceuticae - DPharmen_US
dc.description.abstractBackground: The use of antiretroviral drugs (ARVDs) in the treatment of HIV/AIDS have been promising and effective especially amongst adults as it suppresses the viral load, thereby improving the life expectancy of HIV patients. However, the adoption of the treatment amongst children living with HIV have proved to be challenging. This is because of the poor drug adherence or non-compliance resulting from the lack of child-friendly formulations. The dosage forms are typically large tablets which have led to difficulty in swallowing or needs breaking of the tablets to obtain the correct dose and potentially some sort of dosage form manipulation by mixing it with milk or juice. The limited paediatric formulations that are available are mostly unpalatable, despite being formulated in a syrup or liquid, it still presents with a bitter taste. Therefore, all these factors combined have emphasized the need for child friendly dosage forms for children suffering from this debilitating disease.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15061
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectMicroencapsulationen_US
dc.subjectHIV/AIDSen_US
dc.subjectPaediatricen_US
dc.subjectAmorphous dispersionsen_US
dc.subjectLiposomesen_US
dc.titleInvestigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugsen_US
dc.typeThesisen_US

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