Environmental contaminants and male infertility: Effects and mechanisms

Simple item page
dc.contributor.authorHenkel, R
dc.contributor.authorSelvaraju, V
dc.contributor.authorBaskaran, S
dc.date.accessioned2021-05-31T11:04:32Z
dc.date.available2021-05-31T11:04:32Z
dc.date.issued2021
dc.description.abstractThe escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth and function of male reproductive organs. Several epidemiological reports have correlated the blood and seminal levels of environmental contaminants with poor sperm quality. Numerous in vivo and in vitro studies have been conducted to investigate the effect of various environmental contaminants on spermatogenesis, steroidogenesis, Sertoli cells, blood–testis barrier, epididymis and sperm functions. The reported reprotoxic effects include alterations in the spermatogenic cycle, increased germ cell apoptosis, inhibition of steroidogenesis, decreased Leydig cell viability, impairment of Sertoli cell structure and function, altered expression of steroid receptors, increased permeability of blood–testis barrier, induction of peroxidative and epigenetic alterations in spermatozoa resulting in poor sperm quality and function.en_US
dc.identifier.citationHenkel, R. et al. (2021). Environmental contaminants and male infertility: Effects and mechanisms. Andrologia, 53(1),e13646en_US
dc.identifier.issn03034569
dc.identifier.uri10.1111/and.13646
dc.identifier.urihttp://hdl.handle.net/10566/6231
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectEndocrine disruptorsen_US
dc.subjectEnvironmental contaminantsen_US
dc.subjectMale infertilityen_US
dc.subjectSpermatogenesisen_US
dc.subjectSteroidogenesisen_US
dc.titleEnvironmental contaminants and male infertility: Effects and mechanismsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
and.13646.pdf
Size:
868.84 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Medical Bioscience)