Impact of maternal ART on mother-to-child transmission (MTCT) of HIV at six weeks postpartum in Rwanda

dc.contributor.authorMugwaneza, Placidie
dc.contributor.authorLyambabaje, Alexandre
dc.contributor.authorUmubyeyi, Aline
dc.contributor.authorHumuza, James
dc.contributor.authorTsague, Landry
dc.contributor.authorMwanyumba, Fabian
dc.contributor.authorMutabazi, Vincent
dc.contributor.authorNsanzimana, Sabin
dc.contributor.authorRibakare, Muhayimpundu
dc.contributor.authorIrakoze, Ange
dc.contributor.authorMutaganzwa, Emmanuel
dc.contributor.authorLombard, Carl
dc.contributor.authorJackson, Debra
dc.date.accessioned2018-11-22T06:47:11Z
dc.date.available2018-11-22T06:47:11Z
dc.date.issued2018
dc.description.abstractBACKGROUND: In 2010, Rwanda adopted ART for prevention of mother to child transmission of HIV from pregnant women living with HIV during pregnancy and breasfeeding period. This study examines rates of mother-to-childtransmission of HIV at 6–10 weeks postpartum and risk factors for mother-to-child transmission of HIV (MTCT) among HIV infected women on ART during pregnancy and breastfeeding. METHODS: A cross-sectional survey study was conducted between July 2011–June 2012 among HIV-exposed infants aged 6–10 weeks and their mothers/caregivers. Stratified multi-stage, probability proportional to size and systematic sampling to select a national representative sample of clients. Consenting mothers/caregivers were interviewed on demographic and program interventions. Dry blood spots from HIV-exposed infants were collected for HIV testing using DNA PCR technique. Results are weighted for sample realization. Univariable analysis of socio-demographic and programmatic determinants of early mother-to-child transmission of HIV was conducted. Variables were retained for final multivariable models if they were either at least of marginal significance (p-value < 0.10) or played a confounding role (the variable had a noticeable impact > 10% change on the effect estimate). RESULTS: The study sample was 1639 infants with HIV test results. Twenty-six infants were diagnosed HIV-positive translating to a weighted MTCT estimate of 1.58% (95% CI 1.05–2.37%). Coverage of most elimination of MTCT (EMTCT) program interventions, was above 80, and 90.4% of mother-infant pairs received antiretroviral treatment or prophylaxis. Maternal ART and infant antiretroviral prophylaxis (OR 0.01; 95%CI 0.001–0.17) and maternal age older than 25 years were significantly protective (OR 0.33; 95%CI 0.14–0.78). No disclosure of HIV status, not testing for syphilis during pregnancy and preterm birth were significant risk factors for MTCT. Factors suggesting higher sociodemographic status (flush toilet, mother self-employed) were borderline risk factors for MTCT. CONCLUSION: ART for all women during pregnancy and breastfeeding was associated with the estimated low MTCT rate of 1.58%. Mothers who did not receive a full package of anti-retroviral therapy according to the Rwanda EMTCT protocol, and young and single mothers were at higher risk of MTCT and should be targeted for support in preventing HIV infection.en_US
dc.identifier.citationMugwaneza, P. et al. (2018). Impact of maternal ART on mother-to-child transmission (MTCT) of HIV at six weeks postpartum in Rwanda. BMC Public Health, 18: 1248en_US
dc.identifier.issn1471-2458
dc.identifier.urihttps://doi.org/10.1186/s12889-018-6154-6
dc.identifier.urihttp://hdl.handle.net/10566/4220
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherBMCen_US
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.status.ispeerreviewedTRUE
dc.subjectEMTCTen_US
dc.subjectHIVen_US
dc.subjectOperational effectivenessen_US
dc.subjectSentinel surveyen_US
dc.subjectRwandaen_US
dc.subjectMTCTen_US
dc.subjectEMTCT surveillanceen_US
dc.subjectMaternal ARTen_US
dc.titleImpact of maternal ART on mother-to-child transmission (MTCT) of HIV at six weeks postpartum in Rwandaen_US
dc.typeArticleen_US

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