Pharmacological evaluation of some central nervous system effects of Cotyledon Orbiculata

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dc.contributor.advisorAmabeoku, George J.
dc.contributor.advisorGreen, Ivan R.
dc.contributor.authorKabatende, Joseph
dc.contributor.otherSchool of Pharmacy
dc.contributor.otherFaculty of Science
dc.date.accessioned2013-06-13T07:50:25Z
dc.date.accessioned2024-05-15T07:43:04Z
dc.date.available2007/03/30 10:53
dc.date.available2007/03/30
dc.date.available2013-06-13T07:50:25Z
dc.date.available2024-05-15T07:43:04Z
dc.date.issued2005
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractThe use of traditional medicine through the use of medicinal plants in Africa and especially in South Africa has long been considered an important characteristic of people's daily lives and socio-cultural heritage. Cotyledon Orbiculata is among the medicinal plants that are used by South African traditional practitioners for the treatment of epilepsy and painful conditions such as corns, warts, toothache, earache, boils and various other ailments. However, the claim of therapeutic successes of medicinal plants by traditional medicine practitioners are hardly subjected to scientific scrutiny. This study therefore, investigated the anti-epileptic property of Cotyledon Orbiculata by studying the effects of the methanol extract of the plant against chemically induced seizures by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid in mice. The study also investigated the analgestic effects of Cotyledon Orbiculata by studying the effect of the plant extract on pain induced by acetic acid and hot plate thermal stimulation.en_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/15184
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectMedicinal plantsen_US
dc.subjectSouth Africaen_US
dc.subjectMateria medicaen_US
dc.subjectVegetableen_US
dc.subjectTraditional medicineen_US
dc.subjectPharmaceutical chemistryen_US
dc.subjectPharmacognosy South Africaen_US
dc.subjectEpilepsyen_US
dc.subjectChemotherapyen_US
dc.subjectTreatmenten_US
dc.titlePharmacological evaluation of some central nervous system effects of Cotyledon Orbiculataen_US
dc.typeThesisen_US

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