Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes

Simple item page
dc.contributor.authorAdamude, Fatima Amin
dc.contributor.authorDingwoke, Emeka John
dc.contributor.authorKlein, Ashwil
dc.date.accessioned2023-04-24T09:25:28Z
dc.date.available2023-04-24T09:25:28Z
dc.date.issued2023
dc.description.abstractEnvenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E. ocellatus and B. arietans) and elapidae (N. haje and N. katiensis) families are presented in this study. Two-dimensional electrophoresis was combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry to analyze the venoms. Proteins were identified by comparing mass spectrometry spectra to those in the reviewed Uniprot-Serpentes database. A protein spot was considered differentially present between samples at a p-value of < 0.05 and a fold change of >2. Viper venoms contained cytotoxic-inducing proteins such as SVMPs, SVSPs, and cytotoxins, whereas elapid snake venoms contained neurotoxic proteins such as PLA2, 3-FTx, and neurotoxins.en_US
dc.identifier.citationAdamude, F. A. et al. (2023). Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes. Scientific African, 20, e01622. https://doi.org/10.1016/j.sciaf.2023.e01622en_US
dc.identifier.issn2468-2276
dc.identifier.urihttps://doi.org/10.1016/j.sciaf.2023.e01622
dc.identifier.urihttp://hdl.handle.net/10566/8869
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectProteomicsen_US
dc.subjectSnake venomen_US
dc.subjectBiotechnologyen_US
dc.subjectReptileen_US
dc.subjectNigeriaen_US
dc.titleComparative venom toxin analyses of Nigerian viperidae and elapidae snakesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
adamude_comparative venom toxin analyses of nigeria_2023.pdf
Size:
1.7 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Biotechnology)