An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
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Date
2007
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Retinoblastoma binding prot
ein 6 (RBBP6) is a 250 kDa human splicing-associated
protein that is also known to
interact with tumour suppresso
r proteins p53 and pRb and to
mediate ubiquitination of p53 via its intera
ction with Hdm2. RBBP6 is highly up
regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.
Description
Magister Scientiae - MSc
Keywords
15N-HSQC, 1H-113Cd-HSQC, Cadmium ion, Coordination, Expression, RING, Spectroscopy, Zinc ion