Cardiovascular effects of the alkaloid hippadine on the isolated perfused rat heart

dc.contributor.authorMugabo, Pierre
dc.contributor.authorObikeze, Kenechukwu
dc.contributor.authorNjagi, Angela
dc.contributor.authorBurger, Andries
dc.contributor.authorDietrich, Danielle
dc.contributor.authorGreen, Ivan
dc.date.accessioned2012-08-08T13:12:09Z
dc.date.available2012-08-08T13:12:09Z
dc.date.issued2012
dc.description.abstractCrinum macowanii has been used extensively in traditional medicines for treatment of various illnesses such as oedema and ‘heart disease’. Previous studies of the crude bulb extracts on Langendorff perfused isolated rat hearts indicated a positive inotropic effect. The aim of this study was to isolate and characterize compound(s) from C. macowanii with cardiovascular effects similar to that observed with the crude extracts of the plant. The methanol extract of dried bulbs was extracted for alkaloids, and structural elucidation of the isolated alkaloid identified it as hippadine. The cardiovascular effects of hippadine was evaluated in vitro in isolated perfused rat hearts using the “double sided” working heart system. Perfusion with 0.5 μg/ml and 5.0 μg/ml hippadine in Krebs-Hanseleit buffer led to significant decreases in coronary flow, aortic output, cardiac output, systolic pressure, and heart rate, accompanied by increases in diastolic pressure. Hippadine exhibited a negative chronotropic and inotropic effect on the isolated rat heart and is responsible either partly or fully for the cardiovascular effects of C. macowanii.en_US
dc.identifier.citationMugabo, P.; Obikeze, K.; Ngaji, A,; Burger, A.P.; Green, I.; Dietrich, D.D. (2012). Cardiovascular effects of the alkaloid hippadine on the isolated perfused rat heart. International Journal of Medicinal and Aromatic Plants, 2(1): 172-177en_US
dc.identifier.issn2249-4340
dc.identifier.urihttp://hdl.handle.net/10566/401
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherOpen Access Science Research Publisheren_US
dc.rightsCopyright © Open Access Science Research Publisher. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 2.5 India License.
dc.status.ispeerreviewedtrue
dc.subjectAlkaloiden_US
dc.subjectCardiovascular effectsen_US
dc.subjectCrinum macowaniien_US
dc.subjectHippadineen_US
dc.subjectRatsen_US
dc.titleCardiovascular effects of the alkaloid hippadine on the isolated perfused rat hearten_US
dc.typeArticleen_US

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