Towards bioactive dental restorative materials with chitosan and nanodiamonds: evaluation and application

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dc.contributor.authorMulder, Riaan
dc.contributor.authorGrobler, Sias Renier
dc.contributor.authorMoodley, Desi
dc.contributor.authorPerchyonok, Tamara
dc.date.accessioned2015-09-23T07:20:51Z
dc.date.available2015-09-23T07:20:51Z
dc.date.issued2015
dc.description.abstractBACKGROUND/PURPOSES: Recently various articles showed beneficial effects of the addition of different the beneficial effect (bond strength and longevity) of the addition of different bioactive compounds towards dental materials. compounds towards dental materials. Therefore, the aim of this work was to evaluate the effect of the addition of bioactive materials and combination thereof (chitosan/nanodiamond or cyclodextrin/nanodiamond) to a dental composite. MATERIALS AND METHODS: The flowable composite Premise by Kerr was used as the standard control dental material. Premisewas also modified to contain: 10% nanodiamonds/Premise, 10% chitosan/nanodiamonds/Premise, 10% cyclodextrin/ nanodiamonds/Premise and 10% cyclodextrin/Premise and tested for their dentin bond strength, volumetric shrinkage, Vickers hardness and cytotoxicity. RESULTS AND CONCLUSION: Beneficial effects of the addition of different bioactive compounds towards dental materials were proved. A higher shear bond strength (p < 5%) was found after 3 months of Premise treated with nanodiamonds, chitosan, cyclodextrin (CD) and combinations thereof than the control Premise. The sequence for the Vickers hardness was: CD (32.5) < nano (34.8) < CD Nano (38.8) < Premise (39) < Chitosan Nano (42.2). Chitosan was found to increase the mouse 3T3 fibroblast cell survival rate (113%), while nanodiamonds (92%) and the combination of chitosan + nanodiamonds (93%) showed little cytotoxicity. The shrinkage was lower for all the additions than for Premise alone. Nanodiamonds and the combination chitosan + nanodiamonds showed little cytotoxicity towards mouse 3T3 fibroblast cells.en_US
dc.description.accreditationWeb of Scienceen_US
dc.description.sponsorshipWe acknowledge financial support from SADA and UWC Dental faculty Dean.en_US
dc.identifier.citationGrobler, S. R. et al. (2015). Towards bioactive dental restorative materials with chitosan and nanodiamonds: evaluation and application. International Journal of Dentistry Oral Science, 2(9): 147-154en_US
dc.identifier.issn2377-8075
dc.identifier.urihttp://hdl.handle.net/10566/1662
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherSciDoc Publishersen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
dc.status.ispeerreviewedtrue
dc.subjectNanodiamondsen_US
dc.subjectChitosanen_US
dc.subjectCytotoxicityen_US
dc.subjectDental Materialen_US
dc.titleTowards bioactive dental restorative materials with chitosan and nanodiamonds: evaluation and applicationen_US
dc.typeArticleen_US

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