Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+

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dc.contributor.authorEnogieru, A.B
dc.contributor.authorHaylett, W
dc.contributor.authorHiss, D.C
dc.date.accessioned2021-05-31T10:37:42Z
dc.date.available2021-05-31T10:37:42Z
dc.date.issued2021
dc.description.abstractAccumulating evidence suggest that apoptosis, autophagy and dysregulation of signaling pathways are common mechanisms involved in Parkinson’s disease (PD) pathogenesis, and thus development of therapeutic agents targeting these mechanisms may be useful for the treatment of this disease. Although rutin (a bioflavonoid) is reported to have pharmacological benefits such as antioxidant, anti-inflammatory and antitumor activities, there are very few reports on the activity of this compound in 1-methyl-4-phenylpyridinium (MPP+)-induced PD models. Accordingly, we investigated the effects of rutin on apoptosis, autophagy and cell signaling markers (AKT/AMPK) in SH-SY5Y cells exposed to MPP+. Results show reduced changes in nuclear morphology and mitigation of caspase 3/7 and 9 activities in rutin pre-treated cells exposed to MPP+. Likewise, rutin regulated cell signaling pathways (AKT/AMPK) and significantly decreased protein expression levels of cleaved PARP, cytochrome c, LC3-II and p62.en_US
dc.identifier.citationEnogieru, A.B. et al. (2021). Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+. Metabolic Brain Disease, 36(2), 315-326en_US
dc.identifier.issn0885-7490
dc.identifier.uri10.1007/s11011-020-00641-z
dc.identifier.urihttp://hdl.handle.net/10566/6226
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectCell signalingen_US
dc.subjectMPPen_US
dc.subjectRutinen_US
dc.titleRegulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+en_US
dc.typeArticleen_US

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