The Use of Probiotics in the Primary Prevention of Atopic Dermatitis: A Systemic Review of the Literature in Light of the Hygiene Hypothesis
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Date
2012
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
8th Conference of the Federation of African Immunological Societies
Abstract
Atopic dermatitis (eczema) is a type 1 hypersensitivity reaction that is common in infants and
young children, with incidence increasing in the Industrialised world. Based on epidemiological
evidence, the hygiene hypothesis proposes that reduced exposure to infective organisms is
associated with immune dysfunction (Seroni et al., 2010). Caesarean sections, lack of breast
feeding, lack of exposure to micro-organisms and parasites in early life, widespread use of
antibiotics and a more hygienic or clean environment is closely associated with the development
of atopic dermatitis. This is explained by type 2 helper T-lymphocyte (Th2) cell dominance and a
reduction in T-regulatory (Treg) cell function due to lack of stimulation via infectious organisms
(Boon et al., 2006; Seroni et al., 2010) (Fig. 1). Furthermore, altered gut microbiota and dysbiosis
due to similar risk factors has been implicated in the development of atopic dermatitis (Kranich et
al, 2011). There has been recent interest in the use of probiotics in the prevention of atopic
dermatitis. The terms atopic dermatitis and atopy are incorrectly used interchangeable in much
of the literature, and this study will follow this protocol.
Description
Keywords
Probiotics, Primary Prevention, Atopic Dermatitis, Hygiene Hypothesis
Citation
Linde, Carmen & Wang, Xu & Leisegang, Kristian. (2012). The Use of Probiotics in the Primary Prevention of Atopic Dermatitis: A Systemic Review of the Literature in Light of the Hygiene Hypothesis. 10.13140/RG.2.2.25922.30409.