A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis
| dc.contributor.author | Nsuami, Mozart U. | |
| dc.contributor.author | Witbooi, Peter J. | |
| dc.date.accessioned | 2018-03-01T09:48:09Z | |
| dc.date.available | 2018-03-01T09:48:09Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Antiretroviral treatment (ART) and oral pre-exposure prophylaxis (PrEP) have recently been used efficiently in management of HIV infection. Pre-exposure prophylaxis consists in the use of an antiretroviral medication to prevent the acquisition of HIV infection by uninfected individuals. We propose a new model for the transmission of HIV/AIDS including ART and PrEP. Our model can be used to test the effects of ART and of the uptake of PrEP in a given population, as we demonstrate through simulations. The model can also be used to estimate future projections of HIV prevalence. We prove global stability of the disease-free equilibrium. We also prove global stability of the endemic equilibrium for the most general case of the model, i.e., which allows for PrEP individuals to default. We include insightful simulations based on recently published South-African data. | en_US |
| dc.identifier.citation | Nsuami, M.U. & Witbooi, P.J. (2018). A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis. Advances in Difference Equations, 2018:11 | en_US |
| dc.identifier.issn | 1687-1839 | |
| dc.identifier.uri | https://dx.doi.org/10.1186/s13662-017-1458-x | |
| dc.identifier.uri | http://hdl.handle.net/10566/3554 | |
| dc.language.iso | en | en_US |
| dc.privacy.showsubmitter | FALSE | |
| dc.publisher | SpringerOpen | en_US |
| dc.rights | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
| dc.status.ispeerreviewed | TRUE | |
| dc.subject | HIV/AIDS model | en_US |
| dc.subject | Basic reproduction number | en_US |
| dc.subject | Pre-exposure prophylaxis | en_US |
| dc.subject | Stability | en_US |
| dc.title | A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis | en_US |
| dc.type | Article | en_US |