Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities

Simple item page
dc.contributor.advisorJoubert, Jacques
dc.contributor.advisorMalan, Sarel
dc.contributor.advisorEgieyeh, Samuel
dc.contributor.authorPokomi, Rostand Fankam
dc.date.accessioned2021-03-09T10:12:51Z
dc.date.accessioned2024-10-29T13:17:59Z
dc.date.available2021-03-09T10:12:51Z
dc.date.available2024-10-29T13:17:59Z
dc.date.issued2020
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractMalaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action. Natural products (NP) provide a wide diversity of compounds with unique scaffolds, as such, a library of virtual compounds (VC) designed from natural products with antiplasmodial activities (NAA) can be a worthy starting point.en_US
dc.identifier.urihttps://hdl.handle.net/10566/16352
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectChloroquine resistanceen_US
dc.subjectDrug resistanceen_US
dc.subjectCheminformaticsen_US
dc.titleSelection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activitiesen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
pokomi_m_nsc_2020.pdf
Size:
13.36 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Magister Scientiae - MSc (Pharmaceutical Chemistry)