Metagenomics, gene discovery and the ideal biocatalyst

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dc.contributor.authorCowan, Donald A.
dc.contributor.authorArslanoglu, A.
dc.contributor.authorBurton, Stephanie G.
dc.contributor.authorCameron, Rory A.
dc.contributor.authorBaker, Gillian
dc.contributor.authorSmith, Jacques J.
dc.contributor.authorMeyer, Quinton
dc.date.accessioned2010-09-20T09:34:02Z
dc.date.available2010-09-20T09:34:02Z
dc.date.issued2004
dc.description.abstractWith the rapid development of powerful protein evolution and enzyme-screening technologies, there is a growing belief that optimum conditions for biotransformation processes can be established without the constraints of the properties of the biocatalyst. These technologies can then be applied to find the ‘ideal biocatalyst’ for the process. In identifying the ideal biocatalyst, the processes of gene discovery and enzyme evolution play major roles. However, in order to expand the pool genes for in vitro evolution, new technologies, which circumvent the limitations of microbial culturability, must be applied. These technologies, which currently include metagenomic library screening, gene-specific amplification methods and even full metagenomic sequencing, provide access to a volume of ‘sequence space’ that is not addressed by traditional screening.en_US
dc.identifier.citationCowan, D.A., et al.(2004). Metagenomics, gene discovery and the ideal biocatalyst. Biochemical Society Transactions, 32:298–302
dc.identifier.urihttp://hdl.handle.net/10566/142
dc.language.isoenen_US
dc.privacy.showsubmittertrue
dc.publisherPortland Pressen_US
dc.rightsCopyright 2004 Biochemical Society.
dc.source.urihttp://dx.doi.org/10.1042/BST0320298
dc.status.ispeerreviewedtrue
dc.subjectBiocatalysten_US
dc.subjectGene discoveryen_US
dc.subjectHyperthermophilesen_US
dc.subjectMetagenomeen_US
dc.subjectSequence spaceen_US
dc.subjectUnculturableen_US
dc.titleMetagenomics, gene discovery and the ideal biocatalysten_US
dc.typeArticleen_US

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