One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola

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dc.contributor.authorSibuyi, Nicole R.S.
dc.contributor.authorFadaka, Adewale O.
dc.contributor.authorAnadozie, Scholastica O.
dc.contributor.authorAdewale, Olusola B.
dc.contributor.authorIsitua, Chinwe C.
dc.contributor.authorDavids, Hajierah
dc.contributor.authorRoux, Saartjie
dc.date.accessioned2023-03-30T10:29:57Z
dc.date.available2023-03-30T10:29:57Z
dc.date.issued2023-02
dc.description.abstractRecently, biogenic synthesis of gold nanoparticles (AuNPs) has become a focus area in cancer research owing to the eco-friendliness and cost effectiveness of the synthetic method. In this study, aqueous extract of Garcinia kola seed (AEGKs) was used for the bio-reduction of Au3+ to Au0. The synthesised AEGKs-AuNPs was characterised by ultraviolet-visible (UV-Vis) spectroscopy, dynamic light scattering (DLS), high-resolution transmission electron microscopy (HRTEM) and Fourier transform-infrared (FT-IR) spectroscopy. The in vitro antioxidant activity of the AEGKs and AEGKs-AuNPs was evaluated using 2,2-diphenyl-1-picrylhydrazyl radical scavenging ability and ferric reducing antioxidant power assays. The AEGKs-AuNPs showed an absorption maximum at 512 nm, and the HRTEM images revealed mostly, spherical-shaped AuNPs in the size range of 2–17 nm. The FT-IR spectroscopy revealed that polyphenolic compounds and proteins were predominant, and responsible for the reduction and capping of the AuNPs. The AEGKs-AuNPs showed concentration dependent antioxidant activities, while dose dependent in vitro anti-cancer activity of the AEGKs-AuNPs was demonstrated against lungs, prostrate, human cervical and human colon cancer cells, using the 3-(4,5-dimethylthiazol-2-yl)− 2,5-diphenyltetrazolium bromide tetrazolium reduction (MTT) assay. The antioxidant and anti-cancer activities of the AEGKs-AuNPs could be attributed to the presence of phytochemicals and physicochemical properties of the AuNPs.en_US
dc.identifier.citationAnadozie, Adewale, O. B., Sibuyi, N. R. S., Fadaka, A. O., Isitua, C. C., Davids, H., & Roux, S. (2023). One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola. Process Biochemistry (1991), 128, 49–57. https://doi.org/10.1016/j.procbio.2023.02.010en_US
dc.identifier.urihttps://doi.org/10.1016/j.procbio.2023.02.010
dc.identifier.urihttp://hdl.handle.net/10566/8713
dc.subjectAntioxidanten_US
dc.subjectAnti-canceren_US
dc.subjectBiogenicen_US
dc.subjectGarcinia kolaen_US
dc.subjectGold nanoparticlesen_US
dc.titleOne-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kolaen_US
dc.typeArticleen_US

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