Anaerobes and bacterial vaginosis in pregnancy: virulence factors contributing to vaginal colonisation

dc.contributor.authorAfrica, Charlene W.J.
dc.contributor.authorNel, Janske
dc.contributor.authorStemmet, Megan C.
dc.date.accessioned2014-08-12T11:30:58Z
dc.date.available2014-08-12T11:30:58Z
dc.date.issued2014
dc.description.abstractThe aetiology and pathogenesis of bacterial vaginosis (BV) is unclear but it appears to be associated with factors that disrupt the normal acidity of the vagina thus altering the equilibrium between the normal vaginal microbiota. BV has serious implications for female morbidity, including reports of pelvic inflammatory disease, adverse pregnancy outcomes, increased susceptibility to sexually transmitted infections and infertility. This paper reviewed new available information regarding possible factors contributing to the establishment of the BV vaginal biofilm, examined the proposed role of anaerobic microbial species recently detected by new culture-independent methods and discusses developments related to the effects of BV on human pregnancy. The literature search included Pubmed (NLM), LISTA (EBSCO), and Web of Science. Because of the complexity and diversity of population groups, diagnosis and methodology used, no meta-analysis was performed. Several anaerobic microbial species previously missed in the laboratory diagnosis of BV have been revealed while taking cognisance of newly proposed theories of infection, thereby improving our understanding and knowledge of the complex aetiology and pathogenesis of BV and its perceived role in adverse pregnancy outcomes.en_US
dc.description.accreditationWeb of Scienceen_US
dc.description.sponsorshipNational Research Foundation of South Africa (NRF)en_US
dc.identifier.citationAfrica, C.W.J. et al. (2014). Anaerobes and bacterial vaginosis in pregnancy: virulence factors contributing to vaginal colonisation. International Journal of Environmental Research and Public Health, 11(7): 6979-7000en_US
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10566/1173
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.rights© 2014 Africa, Nel & Stemmet; licensee Multidisciplinary Digital Publishing Institute. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttp://dx.doi.org/10.3390/ijerph110706979
dc.status.ispeerreviewedtrue
dc.subjectPregnancy outcomesen_US
dc.subjectBacterial vaginosisen_US
dc.subjectFemale morbidityen_US
dc.subjectMicrobial ecologyen_US
dc.titleAnaerobes and bacterial vaginosis in pregnancy: virulence factors contributing to vaginal colonisationen_US
dc.typeArticleen_US

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