In silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapy

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dc.contributor.authorAruleba, Raphael Taiwo
dc.contributor.authorTincho, Marius Belmondo
dc.contributor.authorPretorius, Ashley
dc.date.accessioned2021-10-07T11:23:55Z
dc.date.available2021-10-07T11:23:55Z
dc.date.issued2021
dc.description.abstractSchistosomiasis is a debilitating disease caused by a parasitic flatworm found in fresh- water. With the exponential increase in prevalence, Praziquantel (PZQ) remains the only effective treatment drug, however, resistance to PZQ has been reported recently. There- fore, it is imperative to develop effective alternative anti-schistosomal compounds using bioinformatics-based tools utilizing the broad-spectrum therapeutic capabilities of antimi- crobial peptides (AMPs). AMPs are essential components of the innate immune system and are responsible for complete destruction and immunomodulatory effects in the host defence against pathogens. Here, Hidden Markov model was used to identify six anti- microbial peptides (TAK1–TAK6) with potential anti-schistosomal capabilities. Also, glyco- syltransferase and axonemal dynein intermediate chain protein were identified as impor- tant druggable Schistosome proteins. The 3-D structures of the AMPs and proteins were modelled using I-TASSER and it was shown that the six putative anti-schistosomal AMPs and the two proteins had low C-score, possibly due to lack of available templates for their modelling. Finally, PatchDock was employed to ascertain the interaction between the schis- tosome proteins and the putative AMPs.en_US
dc.identifier.citationAruleba, R. T. et al. (2021). In silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapy. Scientific African, 12, e00804. https://doi.org/10.1016/j.sciaf.2021.e00804en_US
dc.identifier.issn24682276
dc.identifier.uri10.1016/j.sciaf.2021.e00804
dc.identifier.urihttp://hdl.handle.net/10566/6868
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectSchistosomiasisen_US
dc.subjectPraziquantel drugen_US
dc.subjectBiotechnologyen_US
dc.subjectProteinsen_US
dc.titleIn silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapyen_US
dc.typeArticleen_US

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