Nanotechnology advances towards development of targeted-treatment for obesity

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dc.contributor.authorSibuyi, Nicole Remaliah Samantha
dc.date.accessioned2021-04-12T13:26:47Z
dc.date.available2021-04-12T13:26:47Z
dc.date.issued2019
dc.description.abstractObesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone or in combination with either lifestyle modifcation or surgery, is reliable in maintaining a healthy body weight, and preventing progression to obesity-induced diseases. However, the anti-obesity drugs are limited by non-specifcity and unsustainable weight loss efects. As such, novel and improved approaches for treatment of obesity are urgently needed. Nanotechnology-based therapies are investigated as an alternative strategy that can treat obesity and be able to overcome the drawbacks associated with conventional therapies. The review presents three nanotechnology-based anti-obesity strategies that target the white adipose tissues (WATs) and its vasculature for the reversal of obesity. These include inhibition of angiogenesis in the WATs, transformation of WATs to brown adipose tissues (BATs), and photothermal lipolysis of WATs. Compared to conventional therapy, the targeted-nanosystems have high tolerability, reduced side efects, and enhanced efcacy. These efects are reproducible using various nanocarriers (liposomes, polymeric and gold nanoparticles), thus providing a proof of concept that targeted nanotherapy can be a feasible strategy that can combat obesity and prevent its comorbiditiesen_US
dc.identifier.citationSibuyi et al. (2019) ,J Nanobiotechnology. Nanotechnology advances towards development of targeted-treatment for obesityen_US
dc.identifier.uri10.1186/s12951-019-0554-3
dc.identifier.urihttp://hdl.handle.net/10566/6008
dc.language.isoenen_US
dc.publisherJournal of Nanobiotechnologyen_US
dc.subjectAngiogenesisen_US
dc.subjectNanotechnologyen_US
dc.subjectObesityen_US
dc.subjectTargeted deliveryen_US
dc.subjectWhite adipose tissueen_US
dc.titleNanotechnology advances towards development of targeted-treatment for obesityen_US
dc.typeArticleen_US

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