Synthesis, characterization, and DNA-binding kinetics of new pd(ii) and pt(ii) thiosemicarbazone complexes: Spectral, structural, and anticancer evaluation

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dc.contributor.authorMbugua, Simon Ngigi
dc.contributor.authorNjenga, Lydia W.
dc.contributor.authorOdhiambo, Ruth A.
dc.date.accessioned2021-01-28T08:22:06Z
dc.date.available2021-01-28T08:22:06Z
dc.date.issued2020
dc.description.abstractIn a bid to come up with potential anticancer agents, a class of thiosemicarbazone ligands bearing substituted thiophene were synthesized followed by complexation with various Pd(II) and Pt(II) metal precursors. The ligands (E)-1-((thiophen-2-yl)methylene)thiosemicarbazide (L1), (E)-1-((4-bromothiophen-2-yl)methylene)thiosemicarbazide (L2), and (E)-1-((5-bromothiophen-2-yl)methylene)thiosemicarbazide (L3) were synthesized by condensation reactions and obtained in good yields. Complexation of L1 and L2 with Pd(cod)Cl2 gave C1 (C6H7Cl2N3PdS2) and C2 (C6H6BrCl2N3PdS2), respectively. Complexation of L1 with K2PtCl4 gave C3 (C6H7Cl2N3PtS2), while L3 with K2PtCl2[(PPh)3]2 gave C4 (C24H21BrClN3PPtS2). The structures and coordination for all compounds were established by FTIR, 1H-NMR, 13C-NMR, UV-Vis, elemental analysis, and single-crystal X-ray diffraction studies for ligand L1. Tuning of the spectral and anticancer activity of the compounds was investigated by changing the position of the bromide substituent, metal center, and the σ or π-donor/acceptor strength of the groups surrounding the metal center.en_US
dc.identifier.citationMbugua, S. N. et al. (2020). Synthesis, characterization, and DNA-binding kinetics of new pd(ii) and pt(ii) thiosemicarbazone complexes: Spectral, structural, and anticancer evaluation. Journal of Chemistry, 2020,3863269en_US
dc.identifier.issn2090-9071
dc.identifier.uri10.1155/2020/3863269
dc.identifier.urihttp://hdl.handle.net/10566/5790
dc.language.isoenen_US
dc.publisherHindawien_US
dc.subjectDNA-binding Kineticsen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectAnticanceren_US
dc.subjectPd(II) and pt(II) metal precursorsen_US
dc.subjectDNA intercalatorsen_US
dc.titleSynthesis, characterization, and DNA-binding kinetics of new pd(ii) and pt(ii) thiosemicarbazone complexes: Spectral, structural, and anticancer evaluationen_US
dc.typeArticleen_US

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