The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome

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dc.contributor.authorKhalafalla, Kareim
dc.contributor.authorMajzoub, Ahmad
dc.contributor.authorHenkel, Ralf
dc.date.accessioned2021-10-11T11:15:41Z
dc.date.available2021-10-11T11:15:41Z
dc.date.issued2021
dc.description.abstractOur study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed sperm DNA fragmentation testing before the procedure. Based on sperm DNA fragmentation cut-off values, the patients were differentiated into 3 groups as <20%, 20%–30% and >30%. According to the female status, patients were differentiated into favourable group (n = 259) with female age <35 years and anti-Mullerian hormone level ≥7.1 pmol/L; and unfavourable group (n = 133) with female age ≥35 years and anti-Mullerian hormone level ≤7.1 pmol/L. The patient's medical records were reviewed, and patient's demographic, laboratory data including semen analysis, sperm DNA fragmentation determined by means of sperm chromatin dispersion, hormonal profile and data regarding intracytoplasmic sperm injection cycle were collected.en_US
dc.identifier.citationKhalafalla, K. et al. (2021). The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome. Andrologia, 53(10) ,e14180. https://doi.org/10.1111/and.14180en_US
dc.identifier.issn1439-0272
dc.identifier.urihttps://doi.org/10.1111/and.14180
dc.identifier.urihttp://hdl.handle.net/10566/6886
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectClinical reproductive outcomesen_US
dc.subjectSperm injectionen_US
dc.subjectSperm DNA fragmentationen_US
dc.subjectSperm chromatin dispersionen_US
dc.subjectSemen qualityen_US
dc.titleThe effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcomeen_US
dc.typeArticleen_US

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