Imino-quinolyl palladium(II) and platinum(II) complexes: synthesis, characterization, molecular structures and cytotoxic effect

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dc.contributor.authorMotswainyana, William M.
dc.contributor.authorOnani, Martin O.
dc.contributor.authorMadiehe, Abram M.
dc.contributor.authorSaibu, Morounke
dc.contributor.authorJacobs, Jeroen
dc.contributor.authorvan Meervelt, Luc
dc.date.accessioned2014-03-17T20:12:51Z
dc.date.available2014-03-17T20:12:51Z
dc.date.issued2013
dc.description.abstractImino-quinolyl ligands L1-L5 were synthesized by condensation reactions and obtained in good yields. Reactions of the ligands with either PdCl2(cod) or K2[PtCl4] gave the corresponding palladium(II) and platinum(II) complexes 1-10 also in good yields. All the compounds were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy. X-ray crystallography was used to confirm the structures of these compounds. Molecular structures of 3 and 5 showed that the ligands coordinate to the metal centre through the two nitrogen atoms, generating a distorted square planar geometry around the palladium atom. The new complexes exhibited remarkable cytotoxic activities against MCF-7 and HT-29 cancer cell lines.en_US
dc.description.accreditationWeb of Scienceen_US
dc.identifier.citationImino-quinolyl palladium(II) and platinum(II) complexes: synthesis, characterization, molecular structures and cytotoxic effect. Inorganica Chimica Acta, 400: 197–202en_US
dc.identifier.issn0020-1693
dc.identifier.urihttp://hdl.handle.net/10566/1057
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherElsevieren_US
dc.rightsThis is the author postprint version of an article by Elsevier. The file may be freely used, provided that acknowledgement of the source is given.
dc.source.urihttp://dx.doi.org/10.1016/j.ica.2013.02.029
dc.status.ispeerreviewedtrue
dc.subjectImino-quinolylen_US
dc.subjectPalladium
dc.subjectPlatinum
dc.subjectMolecular structures
dc.subjectCancer
dc.subjectCytotoxicity
dc.titleImino-quinolyl palladium(II) and platinum(II) complexes: synthesis, characterization, molecular structures and cytotoxic effecten_US
dc.typeArticleen_US

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