Phytochemical screening and biological activity studies of five South African indigenous medicinal plants

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dc.contributor.authorBabajide, Jelili Olalekan
dc.contributor.authorMabusela, Wilfred T.
dc.contributor.authorGreen, Ivan
dc.contributor.authorAmeer, Farouk
dc.contributor.authorWeitz, Frans
dc.contributor.authorIwuoha, Emmanuel I.
dc.date.accessioned2016-06-08T12:16:59Z
dc.date.available2016-06-08T12:16:59Z
dc.date.issued2010
dc.description.abstractDifferent extracts and fractions of five selected indigenous South African medicinal plants, namely, Cissampelos capensis, Geranium incanum and three Gethyllis species, were subjected to phytochemical screening and testing for cytotoxicity using the brine shrimp lethality bioassay, and antimicrobial activity assays against nine microbes, which included three fungal species, three Gram negative and three Gram positive bacteria.The majority of the extracts tested positive for the presence of tannins, phenolics and flavonoids, while in selected cases, phytochemical tests suggested the presence of essential oils, glycosides or alkaloids. The methanol extract of Gethyllis gregoriana displayed the highest cytotoxicity levels. Generally, the highest levels of biological activity were shown to reside in the methanolic extracts, while hexane extracts revealed very low to zero activity. The total tertiary alkaloid (TTA) of C. capensis was mostly active against Bacillus subtilis, a Gram +ve bacteria. The trends observed for the cytotoxicity assay were in agreement with those observed for the antimicrobial assay.en_US
dc.identifier.citationBabajide, J.O. (2010). Phytochemical screening and biological activity studies of five South African indigenous medicinal plants. Journal of Medicinal Plants Research 2(18): 1924-1932en_US
dc.identifier.issn1991-637X
dc.identifier.urihttp://hdl.handle.net/10566/2296
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherAcademic Journalsen_US
dc.rights.uriAcademic Journals strongly supports the Open Access initiative. Abstracts and full texts of all articles published by Academic Journals are freely accessible to everyone immediately after publication.
dc.source.urihttp://dx.doi.org/10.5897/JMPR09.401
dc.status.ispeerreviewedTRUE
dc.subjectMedicinal plantsen_US
dc.subjectCissampelos capensisen_US
dc.subjectGeranium incanumen_US
dc.subjectphytochemical screeningen_US
dc.subjectBrine shrimpen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectBacteriaen_US
dc.titlePhytochemical screening and biological activity studies of five South African indigenous medicinal plantsen_US
dc.typeArticleen_US

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