Determinants of viral re-suppression among people living with HIV on second-line anti-retroviral therapy at a central hospital in Bulawayo, Zimbabwe
| dc.contributor.author | Musomekwa, Kudakwashe | |
| dc.date.accessioned | 2025-07-23T13:05:02Z | |
| dc.date.available | 2025-07-23T13:05:02Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Background: The human immunodeficiency virus (HIV) pandemic has a staggering global impact, with two thirds of people living with HIV residing in sub-Saharan Africa. While virological failure (i.e. viral load (VL) >1000 RNA copies/ml) is well researched, few studies have investigated the determinants of viral re-suppression (VL<1000copies/ml) among clients on second-line anti-retroviral therapy (ART) regimens. It is necessary to analyse the factors associated with viral re-suppression among people living with HIV (PLHIV) on second-line ART because of the growing number of people who are taking second-line ART. Furthermore, studies indicate the scarcity of data on the efficacy of second-line ART in sub-Saharan Africa. This study aimed to determine the factors that are associated with viral re-suppression among individuals receiving second-line ART at a central hospital in Bulawayo, Zimbabwe. Methodology: A retrospective cohort study design was used where clinical records of 315 participants on a second-line ART regimen from 1 January 2015 to 31 December 2020 were reviewed. Selected clinical and demographic data were extracted from the records and examined against viral re-suppression and retention in care. A bi-variate analysis of the clinical and demographic factors (such as CD4 count and age respectively) was conducted by viral suppression and retention, followed by a multi-variate analysis of the significant factors concerning viral suppression and retention. | |
| dc.identifier.uri | https://hdl.handle.net/10566/20574 | |
| dc.language.iso | en | |
| dc.publisher | Universty of the Western Cape | |
| dc.subject | Viral re-suppression | |
| dc.subject | Second-line | |
| dc.subject | Retention in care | |
| dc.subject | Viral load | |
| dc.subject | Virological failure | |
| dc.title | Determinants of viral re-suppression among people living with HIV on second-line anti-retroviral therapy at a central hospital in Bulawayo, Zimbabwe | |
| dc.type | Thesis |