Antinociceptive and anti-Inflammatory activities of leaf methanol extract of cotyledon orbiculata L. (Crassulaceae)
Loading...
Date
2012
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Leaf methanol extract of C. orbiculata L. was investigated for antinociceptive and anti-inflammatory activities using acetic acid
writhing and hot-plate tests and carrageenan-induced oedema test in mice and rats, respectively. C. orbiculata (100–400 mg/kg, i.p.)
significantly inhibited acetic acid-induced writhing and significantly delayed the reaction time of mice to the hot-plate-induced
thermal stimulation. Paracetamol (300 mg/kg, i.p.) significantly inhibited the acetic acid-induced writhing in mice. Morphine
(10mg/kg, i.p.) significantly delayed the reaction time of mice to the thermal stimulation produced with hot plate. Leaf methanol
extract of C. orbiculata (50–400 mg/kg, i.p.) significantly attenuated the carrageenan-induced rat paw oedema. Indomethacin
(10mg/kg, p.o.) also significantly attenuated the carrageenan-induced rat paw oedema. The LD50 value obtained for the plant
species was greater than 4000 mg/kg (p.o.). The data obtained indicate that C. orbiculata has antinociceptive and anti-inflammatory
activities, justifying the folklore use of the plant species by traditional medicine practitioners in the treatment of painful and
inflammatory conditions. The relatively high LD50 obtained shows that C. orbiculatamay be safe in or nontoxic to mice.
Description
Keywords
Leaf methanol extrac, Anti-inflammatory, Oedema, Paracetamol, Thermal stimulation, Crassulaceae, Cotyledon orbiculata L. (Crassulaceae)
Citation
Amabeoku, G.J. and Kabatende, J. (2012) Antinociceptive and anti-Inflammatory activities of leaf methanol extract of cotyledon orbiculata L. (Crassulaceae). Advances in Pharmacological Sciences, Volume 2012, Article ID 862625. Doi:10.1155/2012/862625