Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study

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dc.contributor.authorKatsidzira, Leolin
dc.contributor.authorLaubscher, Ria
dc.contributor.authorGangaidzo, Innocent T.
dc.contributor.authorSwart, Rina
dc.contributor.authorMakunike-Mutasa, Rudo
dc.contributor.authorManyanga, Tadios
dc.contributor.authorThomson, Sandie
dc.contributor.authorRamesar, Raj
dc.contributor.authorMatenga, Jonathan A.
dc.contributor.authorRusakaniko, Simbarashe
dc.date.accessioned2018-10-22T08:52:21Z
dc.date.available2018-10-22T08:52:21Z
dc.date.issued2018
dc.description.abstractBACKGROUND: The rising incidence of colorectal cancer in sub-Saharan Africa may be partly caused by changing dietary patterns. We sought to establish the association between dietary patterns and colorectal cancer in Zimbabwe. METHODS: One hundred colorectal cancer cases and 200 community-based controls were recruited. Data were collected using a food frequency questionnaire, and dietary patterns derived by principal component analysis. Generalised linear and logistic regression models were used to assess the associations between dietary patterns, participant characteristics and colorectal cancer. RESULTS: Three main dietary patterns were identified: traditional African, urbanised and processed food. The traditional African diet appeared protective against colorectal cancer (Odds Ratio (OR) 0.35; 95% Confidence Interval (CI), 0.21 – 0.58), which had no association with the urban (OR 0.68; 95% CI, 0.43–1.08), or processed food (OR 0.91; 0.58–1.41) patterns. The traditional African diet was associated with rural domicile, (OR 1.26; 95% CI, 1.00–1.59), and a low income (OR1.48; 95% CI, 1.06–2.08). The urbanised diet was associated with urban domicile (OR 1.70; 95% CI, 1.38–2.10), secondary (OR 1.30; 95% CI, 1.07–1.59) or tertiary education (OR 1.48; 95% CI, 1.11–1.97), and monthly incomes of $201–500 (OR 1.30; 95% CI, 1.05–1.62), and the processed food pattern with tertiary education (OR 1.42; 95% CI, 1.05–1.92), and income > $1000/month (OR 1.48; 95% CI, 1.02–2.15). CONCLUSION: A shift away from protective, traditional African dietary patterns may partly explain the rising incidence of colorectal cancer in sub-Saharan Africa.en_US
dc.description.accreditationISI
dc.identifier.citationKatsidzira, L. et al. (2018). Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study. Cancer Epidemiology, 57: 33 – 38.en_US
dc.identifier.issn1877-7821
dc.identifier.urihttp://dx.doi.org/10.1016/j.canep.2018.09.005
dc.identifier.urihttp://hdl.handle.net/10566/4149
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherElsevieren_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1016/j.canep.2018.09.005
dc.status.ispeerreviewedTRUE
dc.subjectColorectal neoplasmsen_US
dc.subjectAfricaen_US
dc.subjectSouth of the Saharaen_US
dc.subjectRisk factorsen_US
dc.subjectIncidenceen_US
dc.subjectDieten_US
dc.subjectZimbabween_US
dc.titleDietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control studyen_US
dc.typeArticleen_US

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