A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
| dc.contributor.advisor | Hide, Winston | |
| dc.contributor.advisor | Christoffels, Alan | |
| dc.contributor.author | Mpondo, Feziwe | |
| dc.date.accessioned | 2022-11-18T11:41:17Z | |
| dc.date.accessioned | 2024-05-17T07:20:02Z | |
| dc.date.available | 2022-11-18T11:41:17Z | |
| dc.date.available | 2024-05-17T07:20:02Z | |
| dc.date.issued | 2009 | |
| dc.description | >Magister Scientiae - MSc | en_US |
| dc.description.abstract | Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly immunity factors are key determinants in the success and failure of infection and the maturation process of parasites. An analysis of tsetse fly immunity factors is limited by the paucity of genomic data for Glossina spp. Nevertheless, completely sequenced and assembled genomes Drosophila melanogaster, Anopheles gambiae and Aedes aegypti provide an opportunity to characterize protein families in species such as G/ossiza by using a comparative genomics approach. In this study, we characterize thioester-containing proteins (TEPs), a sub-family of immunity-related proteins, in Glossinaby leveraging the EST data for G. morsitans and the genomic resources of D. melanogaster, A. gambiae as well as A. aegypti | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/15213 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the western cape | en_US |
| dc.rights.holder | University of the western cape | en_US |
| dc.subject | Glossina morsitans | en_US |
| dc.subject | Sleeping sickness | en_US |
| dc.subject | Insect immunity | en_US |
| dc.subject | Comparative genomics | en_US |
| dc.subject | Thioester-containing proteins | en_US |
| dc.title | A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly | en_US |