The development of a single nucleotide polymorphism database for forensic identification of specified physical traits

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dc.contributor.advisorBajic, Vladimir
dc.contributor.authorNaidu, Alecia Geraldine
dc.contributor.otherNULL
dc.contributor.otherFaculty of Science
dc.date.accessioned2013-12-10T13:33:17Z
dc.date.accessioned2024-05-17T07:20:03Z
dc.date.available2011/02/15 10:55
dc.date.available2011/02/15
dc.date.available2013-12-10T13:33:17Z
dc.date.available2024-05-17T07:20:03Z
dc.date.issued2009
dc.descriptionMagister Scientiae - MScen_US
dc.description.abstractMany Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially useful in forensic investigations. Complex traits such as pigmentation can be predicted from the genome sequence, provided that genes with strong effects on the trait exist and are known. Phenotypic traits may also be associated with variations in gene expression due to the presence of SNPs in promoter regions. In this project, the identification of genes associated with these physical traits of potential forensic relevance have been collated from the literature using a text mining platform and hand curation. The SNPs associated with these genes have been acquired from public SNP repositories such as the International HapMap project, dbSNP and Ensembl. Characterization of different population groups based on the SNPs has been performed and the results and data stored in a MySQL database. This database contains SNP genotyping data with respect to physical phenotypic differences of forensic interest. The potential forensicrelevance of the SNP information contained in this database has been verified through in silico SNP analysis aimed at establishing possible relationships between SNP occurrence and phenotype. The software used for this analysis is MATCH™. Data management and access has been enhanced by the use of a functional web-based front-end which enables the users to extract and display SNP information without running complex Structured Query Language (SQL) statements from the command line. This Forensic SNP Phenotype resource can be accessed at http://forensic.sanbi.ac.za/alecia_forensics/Index.htmlen_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/15220
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectBioinformaticsen_US
dc.subjectForensicsen_US
dc.subjectPigmentationen_US
dc.subjectHeighten_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectPopulationen_US
dc.subjectText-Miningen_US
dc.subjectMySQLen_US
dc.subjectForensic SNP Phenotype Databaseen_US
dc.subjectWeb user interfaceen_US
dc.titleThe development of a single nucleotide polymorphism database for forensic identification of specified physical traitsen_US
dc.typeThesisen_US

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