The immune-modulating activity of Sutherlandia frutescens

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dc.contributor.advisorPool, Edmund J.
dc.contributor.authorKisten, Najwa
dc.contributor.otherNULL
dc.contributor.otherFaculty of Science
dc.date.accessioned2013-09-03T12:49:42Z
dc.date.accessioned2024-10-29T12:48:20Z
dc.date.available2011/03/08 12:08
dc.date.available2011/04/19
dc.date.available2013-09-03T12:49:42Z
dc.date.available2024-10-29T12:48:20Z
dc.date.issued2010
dc.descriptionMagister Scientiae - MScen_US
dc.description.abstractThe aim of this study was to investigate the effects of Sutherlandia frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations of Sutherlandia frutescens were stimulated in vitro with either Lipopolysaccharide (LPS) or Phytohaemagglutinin (PHA). Results show that Sutherlandia frutescens is not toxic at any of the concentrations tested. The addition of Sutherlandia frutescens at high concentrations to the stimulated whole blood cell cultures reflects a significant down regulation of Interleukin(IL) 6 and IL-10 compared to the control (P<0.05) hence suppressed the inflammatory and humoral immune response. Results obtained for Inteferon-gamma (IFN ) shows that Sutherlandia frutescens is donor specific as it reflects both up and down regulation in the release of IFN at the concentrations tested. The in vitro data generated by this study supports the use of Sutherlandia frutescens in the management of inflammatory conditions and allergies such as asthma. However the effects of Sutherlandia frutescens on cell mediated immunity was found to be donor specific. Further investigation of Sutherlandia frutescens on cellular immunity is advised.en_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/16332
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectCell mediated immunityen_US
dc.subjectCytotoxicityen_US
dc.subjectCytokinesen_US
dc.subjectIndigenous herbal medicineen_US
dc.subjectInflammationen_US
dc.subjectHumoral immunityen_US
dc.subjectHuman whole blood cultureen_US
dc.subjectSutherlandia frutescensen_US
dc.titleThe immune-modulating activity of Sutherlandia frutescensen_US
dc.typeThesisen_US

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Magister Scientiae - MSc (Herbal Science and Medicine)