Involvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice

Simple item page
dc.contributor.authorAhmad, A.H.
dc.contributor.authorAmabeoku, G.J.
dc.date.accessioned2018-01-29T10:06:13Z
dc.date.available2018-01-29T10:06:13Z
dc.date.issued2013
dc.description.abstractThe possible involvement of gamma aminobutyric acid (GABA), in the anticonvulsant effect of Ruta graveolens L. was investigated by studying the effect of the leaf methanol extract against seizures elicited by either pentylenetetrazole (PTZ), bicuculline, picrotoxin or N-Methyl-DL-Aspartic acid (NlvIDLA) in mice. Leaf methanol extract of Ruta graveolens, phenobarbitone, diazepam and muscimol significantly antagonized seizures induced by PTZ, bicuculline or picrotoxin. Combined treatment of subeffective doses of R. graveolens and muscimol significantly antagonized seizures induced by PTZ, bicuculline or picrotoxin. Dimethylsulfoxide (DMSO) or phenytoin did not significantly affect the seizures produced by PTZ, bicuculline or picrotoxin. Ruta graveolens, phenobarbitone, diazepam, phenytoin or DMSO did not significantly affect seizures produced by NlvIDLA. LY233053 significantly antagonized seizures produced by NlvIDLA. Combined treatment of sub-effective doses of LY233053 and Ruta graveolens did not significantly alter NlvIDLA-induced seizures. The phytochemical qualitative analysis of the plant species showed the presence of tannins, cardiac glycosides, saponins, flavonoids, triterpene steroids and alkaloids. The LD50 value obtained following oral administration of the leaf methanol extract of R. graveolens was above 4000 mg kg-1 .The HPLC fingerprint of the plant species revealed certain characteristic peaks at 350 run. The data obtained in this study, indicate that the leaf methanol extract of R. graveolens has anticonvulsant activity. The data obtained also indicate that GABA mechanism may probably be involved in the anticonvulsant effect of the plant extract. The relatively high LD50 obtained for the plant species, given orally, indicates that it is safe in mice.en_US
dc.description.accreditationWeb of Science
dc.identifier.citationAhmad, A.H. & Amabeoku, G.J. (2013). Involvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice. International Journal of Pharmacology, 9(2): 134 – 142.en_US
dc.identifier.issn1811-7775
dc.identifier.urihttp://dx.doi.org/10.3923/ijp.2013.134.142
dc.identifier.urihttp://hdl.handle.net/10566/3430
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherAsian Network for Scientific Informationen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.3923/ijp.2013.134.142
dc.status.ispeerreviewedTRUE
dc.subjectRuta graveolensen_US
dc.subjectRutaceaeen_US
dc.subjectAnticonvulsant effecten_US
dc.subjectLeaf methanol extracten_US
dc.subjectGamma aminobutyric aciden_US
dc.subjectMiceen_US
dc.titleInvolvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in miceen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ahmad_Involvement-of-Gamma_2013.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Research Articles (School of Pharmacy)